1323. Substantial Doses of Daptomycin and Rifampin Eradicate S. epidermidis Biofilm in an In Vitro Pharmacodynamic (IVPD) Model
نویسندگان
چکیده
منابع مشابه
Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.
Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2020
ISSN: 2328-8957
DOI: 10.1093/ofid/ofaa439.1505